Closed-loop focused ultrasound
Feedback-guided exposure control for safer and more repeatable therapeutic delivery.
Hohyun (Henry) Lee, Ph.D.
Therapeutic Ultrasound · Microbubbles · Machine Learning
Research Snapshot
Feedback-controlled ultrasound for brain-focused therapies
I develop closed-loop focused ultrasound systems that combine acoustic monitoring, microbubble physics, and machine learning for targeted therapy and diagnosis in the brain.
Microbubble dynamics monitoring
Acoustic methods for reconstructing and interpreting microbubble oscillations.
Machine learning-guided control
Data-driven models for selecting ultrasound regimens and improving targeting outcomes.
Selected Publications
- Data-Driven Feedback Identifies Focused Ultrasound Exposure Regimens for Improved Nanotheranostic Targeting of the Brain Advanced Science, 2026
- Reconstruction of microbubble oscillation dynamics with frequency-domain backpropagation in optically inaccessible environments Results in Engineering, 2026
- Spatially targeted brain cancer immunotherapy with closed-loop controlled focused ultrasound and immune checkpoint blockade Science Advances, 2022